The Many Benefits of Berberine

Berberine is a medicinal compound found in barberry (and other plants).

  • Best known for treating metabolic syndrome.
  • Lowers blood sugar: in patients with type 2 diabetes, fasting blood sugar down 26%, and HbA1c down 18%.
  • 18% reduction in triglycerides.
  • Effectively lowers blood pressure.
  • Most recently studied for its effects against cancer.  Reduced lung cancer cell replication by up to 30%.
  • Decreased the activity of proteins that stimulate cancer spread by 50%.
  • In a previous study, berberine reduced lung cancer tumor size by 74% (animal model of non-small cell lung cancer).

How to Use Berberine: The standard dosage is 500 mg, 3 times daily.

Berberine’s challenges:

  • Limited absorption/poor bioavailability.
  • Poor water solubility.

For enhanced effects, use 250 mg berberine combined with gamma cyclodextrin.

Berberine with a gamma cyclodextrin formulation showed double the effects versus standard berberine (cell study – effect on cancer cells).