One of the world’s oldest botanical adaptogens is ginseng (Panax ginseng). Like all adaptogens, ginseng contains compounds that help the body and mind respond to changing circumstances by strengthening concentration, energy, and stamina.
The plant’s beneficial compounds, including ginsenosides, ginsans, and gintonins, have been the focus of much clinical research, but the effects – for fighting fatigue, boosting libido, and increasing physical resilience — are major points of investigation as well.
This clinical study examined the effects of Korean red ginseng to determine whether the botanical could be energizing and safe at high dosages. One reason for this study was to see if high dosages of Korean red ginseng would cause side effects, including “fireness”, a Traditional Chinese medicinal term for a scorching sensation in the chest, mouth pain, and other responses.
After four weeks, the results of this study showed that the incidents of “fireness” were no greater with the ginseng group than they were with the placebo group. But most importantly, Korean red ginseng had a powerful – and safe – energizing effect to battle fatigue.
One of the best ways to ensure the most benefits from Korean red ginseng is to look for a supplemental form that concentrates specific compounds called “noble ginsenosides”. Also, because many forms of ginseng may be cultivated using harsh chemicals and pesticides, find a ginseng form that is grown without chemicals and doesn’t carry the risk of heavy metals or other pollutants.
Zhang L, Chen X, Cheng Y, et al. Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial. J Ginseng Res. 2019;43(4):676–683.
BACKGROUND: Korean Red Ginseng (KRG) is widely used for strengthening the immune system and fighting fatigue, especially in people with deficiency syndrome. However, there is concern that the long-term application or a high dose of KRG can cause “fireness” (in Chinese) because of its “dryness” (in Chinese). The aim of this study was to assess the safety and efficacy of a 4-week treatment with KRG in participants with deficiency syndrome.
METHODS: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180 Chinese participants were randomly allocated to three groups: placebo control group, participants were given a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in fireness and safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomes were the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM) symptom scale and fatigue self-assessment scale.
RESULTS: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heat symptoms score including Excess fire-heat score and Deficient fire-heat score showed no significant change as compared with placebo treatment, and no clinically significant changes in any safety parameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCM symptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and time-dependent effect. The total effective rate was also significantly increased in the KRG groups.
CONCLUSION: Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of “fireness” related to KRG.